iPS細胞由来心筋細胞の電気生理学:パッチクランプ実験 | Article Information | J-GLOBAL

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Yamamoto, DA. We resected the mass and interposed it with a reversed great saphenous vein. Sustained inhibition from the superior olivary nucleus is known to control the gain of coincidence detection, which allows the sensitivity of NL neurons to ITD tolerate strong-intensity sound. Also included are those embodied in the form of waves eg, transmission over the Internet. We aimed to test the hypothesis that the DPP-4 inhibitor, alogliptin, attenuates vascular oxidative stress and thus inhibits abdominal aortic aneurysm AAA formation.

市場調査レポート: 世界のセンサーパッチ式ECG(心電図)市場:製品タイプ、用途、エンドユーザー、地域別 - 規模、シェア、動向、および予測

世界のセンサーパッチ式ECG(心電図)市場:製品タイプ、用途、エンドユーザー、地域別 - 規模、シェア、動向、および予測. ECG Sensor. Article “T4処理したラットの心房筋の電気生理学的特性(心電図,パッチクランプ法)​” Detailed information of the J-GLOBAL is a service based on the concept of. Article “iPS細胞由来心筋細胞の電気生理学:パッチクランプ実験” Detailed information of the J-GLOBAL is a service based on 心電図 (日本不整脈心電学会誌). 同期した心電図検査 (ECG) と光電式容積脈波記録法. (PPG) の測定を PPG(​光電式容積脈波)と ECG(心電計)向けのシンプ 医療用センサ・パッチ. • ECG. JPA 心電図電極パッチ. CNB 用于十二导联ecg的双电极装置和方法. WOA1 Ekg-gerät.

心電図 パッチ. Adjustment of the diameter of STJ could treat AR secondary to ascending aortic aneurysm with nearly normal aortic cusps.

研究会 第22回 理論心電図研究会 心筋細胞におけるpatch clamp法について パッチ​クランプ法の原理と心筋の単一イオンチャネル電流. Makoto Arita et al. of results for Electrocardiographs. オムロン 携帯型心電計 HCG 心電図印刷ソフト+SDセット. by HCG ¥22,¥22, (¥22,/個)​. gene therapy / thyroid hormone recptors / adenovirus / 遺伝子導入 / 心臓電気生理 / パッチクランプ / 活動電位持続時間 / 一過性外向きK^+電流 / 心電図. MP-P17 パッチ型長時間心電図レコーダが24時間ホルター心電図で捉えられなかった発作. 性心房細動の検出に有用であった2例. 細屋 由紀子1,. この問題を修正するには、添付のパッチを device-tree-generation に適用します。このパッチにより、axi_dma の axistream-connected 属性と.

Keiko Ishihara - My portal - researchmap

サポート · AR# ISE - ソフトウェア パッチを使用するときの MYXILINX 環境変数の使用方法; AR# LogiCORE FIFO Generator v - Programmable. 性受容体刺激 / ムスカリン性受容体刺激 / 心電図 / 洞性徐脈 / 過分極誘発性非特異的カチオン電流 / スローブロック / パッチクランプ / 副交感性心拍調節.心電図 パッチ 心電図所見から鑑別 p波はⅡ.Ⅲ.aVFで 敗血症とは病原体が血液中に seoauditing.ru​パッチ形成後 PopAの動脈微弱だが触知可 以下3. 解剖学をイメージ。 異常所見は. 直ちに脱出心を用手的に還納し, パッチ閉鎖した.術後も不整脈・低血圧など循環管理に難渋し, 心電図でII, III, aVFでのST上昇・Q波の出現, 心筋. 数理モデル · 心筋 · パッチクランプ · イオンチャネル カリウムイオンの濃度により心電図の再分極が起こるのはなぜか?(質疑応答・臨床一般). JPB2 歩行型の長時間装着用心電図記録および失神センサ JPA 薄型の医療監視パッチに対する電気機械コネクタ. なく、心電図(ElectroCardioGraphy:ECG)あるいは した多重電極は、皮膚に付着可能な非伝導性のパッチ、前記非伝導性のパッチ​.

心電図 パッチ.

Profile Information また、イオンチャネル動態の実験的・理論的解析(パッチクランプ法による 心筋Na-channelモデル(1分子2経路モデル)の作成(共著), 倉田 康孝, 心電図, ​年. ECGは、1,ヘルツ、16ビットでサンプリングされ、バイオパッチで記録される。 その後、心拍変動は、静止時および描画中の連続心電図.

便秘がひどいからデュロテップR MTパッチに変更したのに、改善しないのはなぜ 看護師が気をつけたいポイント IABPは、ポンピングのタイミングを心電図. しHCNチャネルの発現量も多い、低い特徴周波数(low-CF)領域の細胞を用いてパッチ記録を行った。 循環(心電図実習) パッチクランプ実験の基本手技.   心電図 パッチ 1 臨床症状 · 2 心電図による診断 · 3 血清マーカーによる診断 · 4 その他の血清 アトロピン適応の指針 · 経皮的パッチとactive(demand)経皮的ペーシング(一時的)​. Day 1,Day 7,及び Day 14 で経時的に心電図で QT 間隔を評価した。 ホルモン剤による避妊法(埋込み型,パッチ薬,経口薬,IM 注射剤). Sumo site patreon com 術直後は良好な循環動態であっ たが、術後 1 日目より心電図波形が著明な低電位 したバイオチューブはパッチ状に形成し、腹部大動脈を動脈パッチを移植.. , 心電図検査, electrocardiography; ECG, 7, 1, , 腎動脈, renal , パッチテスト(貼布試験), patch test; skin test using patch, 7, 1, , 発熱, fever​.

心電図 パッチ

心電図 Vol,No 池口 滋().PR/RR 細胞内灌流法」新パッチ​クランプ実験技術法 岡田泰伸編 吉岡書店 堀江 稔().「先天性 QT. ECG心電図センサー/読み取り機能障害, ECG心电图传感器/读取故障 ドライバ/パッチ, 软件驱动程序/补丁, 소프트웨어 디바이스 드라이버/.  心電図 パッチ ホース修理パッチ&Organization= フクダ電子株式会社製 心電図データマネジメントシステム EFS&Organization=

CNB - 心电图导联信号产生电路以及心电图信号产生方法 - Google Patents

  心電図 パッチ  

心電図 パッチ. 岡田 健次 (大学院医学研究科 医科学専攻) | KUID教員業績管理システム

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心電図 パッチ

Country of ref document : CN. Country of ref document : EP. Country of ref document : US. Country of ref document : JP. Ref country code : DE. Country of ref document : IN. USP true USA1 no. EPB1 no. JPA no. CNB no. WOA1 no. Disposable patch and reusable sensor assembly for use in medical device localization and mapping systems.

USB2 en. Patch and sensor assembly for use in medical device localization and mapping systems. Method of routing electrical current to bodily tissues via implanted passive conductors. JPA ja. A subscription to JoVE is required to view this content. You will only be able to see the first 2 minutes. We recommend downloading the newest version of Flash here, but we support all versions 10 and above.

If that doesn't help, please let us know. Unable to load video. Please check your Internet connection and reload this page. If the problem continues, please let us know and we'll try to help. An unexpected error occurred. Am J Clin Pathol ; - Clin Chem ; - Ruzich RS:Cardiac enzymes. Postgrad Med ; - J Clin Invest ; - Mair J, Artner - Dworzak E, Lechleitner P, et al:Early diagnosis of acute myocardial infarction by a newly developed rapid immunoturbidimetric assay for myoglobin.

Mair J, Morandell D, Genser N, et al:Equivalent early sensitivities of myoglobin, creatine kinase MB mass, creatine kinase isoform ratios, and cardiac troponins I and T for acute myocardial infarction.

J Mol Cell Cardiol ; - Ravkilde J, Horder M, Gerhardt W, et al:Diagnostic performance and prognostic value of serum troponin T in suspected acute myocardial infarction.

Scand J Clin Lab Invest ; - Lindahl B, Venge P, Wallentin L:Relation between troponin T and the risk of subsequent cardiac events in unstable coronary artery disease. Lindahl B, Venge P, Wallentin L:Troponin T identifies patients with unstable coronary artery disease who benefit from long-term antithrombotic protection. Eur Heart J ; - Fulton MB, et al:Sudden death and myocardial infarction. IV National Heart, Lung, and Blood Institute.

Chambless L, et al:Population versus clinical view of case fatality from acute coronary heart disease. Shibata J, Tanazawa S, Hirasawa K, et al:Deaths in early phase of acute myocardial infarction and approaches for reducing the in-hospital and out-hospital case-fetality rates of the disease. Kerber RE, et al:Guidelines for cardiopulmonary resuscitation and emergency cardiac care.

National Heart Attack Alert Program Coordination Committee Access to Care Subcommittee:Staffing and equipping emergency medical services:Rapid indentification and treatment of acute myocardial infarction. Goldstein S, Landis JR, Leighton R, et al:Characteristic of the resuscitated out-of-hospital cardiac victim with coronary heart disease. This is the first report showing the increased expression of YB-1 during muscle regeneration after ischemic injury.

We report the successful surgical repair of a cervical aortic arch and diverticulum with a brain circulation anomaly through a clamshell incision. Because of the reliability of selective antegrade cerebral perfusion and superior exposure, we chose an approach through a clamshell incision. We describe the utility of this approach for treating a cervical aortic arch with a diverticulum. Pluripotent stem cell-derived cardiomyocytes show great promise in regenerating the heart after myocardial infarction; however, several uncertainties exist that must be addressed before clinical trials.

One practical issue is graft survival following transplantation. Although a pro-survival cocktail with Matrigel has been shown to enhance graft survival, the use of Matrigel may not be clinically feasible.

The purpose of this study was to test whether a hyaluronan-based hydrogel, HyStem, could be a substitute for Matrigel. These findings suggest that further studies will be required to enhance not only graft size, but also the maturation of grafted cardiomyocytes. Although short and long-term outcomes of aortic surgeries have been improving over the past decade, the procedure is likely to be asscociated with life-threatening complications such as neurological deficits caused by suboptimal brain protection or heavily diseased aorta.

Contemporary strategies for brain protection are deep hypothermic arrest with or without retrograde cerebral perfusion retrograde cerebral perfusion or selective antegrade cerebral perfusion.

At the moment, majority of evidences failed to show the superiority of selective antegrade cerebral perfusion to retrograde one. Shaggy aorta atherothrombotic aorta was defined as very extensive atheromatous disease with diffuse ulcers associated with soft, loosely held debris and a paucity of actual thrombus and is the prototypical potential embolic source for neurological deficits.

Non-physiological flow during cardiopulmonary bypass causes the detachment of atheroma and consequently the debris was washed away into the carotid arteries. Therefore, meticulous selection of cannulation site and type of cannula a dispersion cannula and complete exclusion of the diseased aorta contributed to avoiding permanent neurological deficits even when atherothrombotic aorta was present.

Shaggy aorta combined with leukoaraiosis, extracranial carotid artery stenosis, and prolonged cardiopulmonary bypass time exponentially increased postoperative transient neurological deficits in patients undergoing total aortic arch replacement, and may therefore deserve special attention. We experienced a case of ventricular assist with both a pulsatile-flow and a continuous-flow pump in a pediatric patient, and herein report the clinical course and characteristics of the pumps.

A 6-year-old female was diagnosed with fulminant myocarditis and transferred to our hospital for mechanical support. After 12 days of extracorporeal membrane oxygenation, we implanted a left ventricular assist device LVAD and a right ventricular assist device RVAD using centrifugal Gyro pumps with a membrane oxygenator in a paracorporeal fashion.

The membrane oxygenator was removed on postoperative day POD 4, and the patient was weaned from the respirator on POD 6. On POD 32, the patient experienced cerebral infarction and the centrifugal Gyro pump was switched to an extracorporeal pulsatile pump.

No thromboembolic event occurred after pump conversion, although continuous administration of vasodilators was required to avoid hypertension. She underwent successfully heart transplantation in the USA after 8 months of ventricular support. A centrifugal pump is considered useful for pediatric patients, as pump flow and blood pressure can be relatively easily controlled in the postoperative acute phase compared with the pulsatile pump.

However, special care should be taken to monitor for thrombus formation when support length becomes longer than 13 days, and a switch to a pulsatile pump should be considered once the hemodynamic status stabilizes. Within 8-year period between and , we treated patient with a strategy of primary thoracic endovascular aortic repair TEVAR.

In-hospital mortality was 4. Thirty-two emergency cases was included and we treated 23 cases of zone 0 debranching TEVAR with chimney techinique in this period. TEVAR was also indicated for emergency and high risk cases even if their anatomical conditions were outside of instruction for use, and utilized for bridging or staged therapy for open surgery in our series.

Standardization and refinement of endovascular procedures is considered to be important to improvement outcomes, and hybrid therapy or back up of open surgery should be collaborated with TEVAR for thoracic aortic aneurysm treatment.

Induced pluripotent stem cells iPSCs constitute a potential source of autologous patient-specific cardiomyocytes for cardiac repair, providing a major benefit over other sources of cells in terms of immune rejection. However, autologous transplantation has substantial challenges related to manufacturing and regulation.

Although major histocompatibility complex MHC -matched allogeneic transplantation is a promising alternative strategy, few immunological studies have been carried out with iPSCs. Here we describe an allogeneic transplantation model established using the cynomolgus monkey Macaca fascicularis , the MHC structure of which is identical to that of humans. The grafted cardiomyocytes survived for 12 weeks with no evidence of immune rejection in monkeys treated with clinically relevant doses of methylprednisolone and tacrolimus, and showed electrical coupling with host cardiomyocytes as assessed by use of the fluorescent calcium indicator G-CaMP7.

Additionally, transplantation of the iPSC-CMs improved cardiac contractile function at 4 and 12 weeks after transplantation; however, the incidence of ventricular tachycardia was transiently, but significantly, increased when compared to vehicle-treated controls. Collectively, our data demonstrate that allogeneic iPSC-CM transplantation is sufficient to regenerate the infarcted non-human primate heart; however, further research to control post-transplant arrhythmias is necessary.

A year-old man with Marfan syndrome who underwent Crawford type II extension aneurysm repair about 9 years ago was referred to our hospital with persistent fever. Computed tomography CT showed air around the mid-descending aortic prosthetic graft. After dissecting the aortic graft particularly focusing on the high-uptake lesions, this patient underwent in situ graft re-replacement of descending aortic graft with a rifampicin-bonded gelatin-impregnated Dacron graft and omentopexy.

The patient remains well without recurrent infection at 3 months after surgery. We evaluated reactive oxygen species ROS expression by dihydroethidium staining and 8-hydroxydeoxyguanosine 8-OHdG; the oxidation product of DNA by immunohistochemical staining.

We also analyzed the effect of GLP-1 signaling on the inflammatory response. Histopathological examination was done on day 28, and the AAA dilatation ratio was calculated. Western blot analysis showed decreased ERK expression. On day 28, it was evident that the lixisenatide had dramatically reduced aneurysm development in the rats. However, the effect of riboflavin on abdominal aortic aneurysm AAA has never been investigated. In the present study, we examined the hypothesis that riboflavin has a protective effect on AAA formation in an experimental rat model.

Riboflavin administration by gastric gavage once per day was started at 3 days before aneurysm preparation. On day 3, SOD activity in aneurysm walls was assayed. On day 7, reactive oxygen species ROS levels were semiquantified by dihydroethidium staining, and the oxidation product of DNA produced by ROS, 8-hydroxydeoxyguanosine 8-OHdG , was measured by immunohistochemical staining.

The extent of graft replacement hemiarch, partial, or total arch replacement was mainly determined by the location of the primary entry. Multivariate analysis revealed preoperative cardiopulmonary resuscitation and visceral organ malperfusion as significant risk factors for in-hospital mortality, but not total arch replacement.

Rates of distal aortic events defined as freedom from surgery for distal aorta dilation or distal arch diameter expanding to 50 mm at 5 years were significantly better in the total arch replacement group than in the non-total arch replacement group The frequency of distal aortic events might be reduced in patients after total arch replacement compared with non-total arch replacement.

Aortoesophageal fistula is a fatal disease which needs immediate control of bleeding and infection. We report a case of aortoesophageal fistula successfully treated with extra-anatomical bypass and complete resection of infected aorta and esophagus following endovascular repair.

He was discharged after reconstruction of esophagus and recurrence of infection has not been observed for the past 5 years. Freedom from greater than mild AR and reoperation at 5 years was Although the indications for VSRR are being expanded, a larger number of expanded indications were associated with poor outcomes in terms of longevity of valve function.

We discuss a rare case of an ascending aorta pseudoaneurysm fistulating into the right atrium following prior aortic and mitral valve replacement. Transthoracic echocardiography and computed tomography revealed a pseudoaneurysm of the ascending aorta attached to the right atrium with fistulous communication. The pseudoaneurysm arose from the center of the former aortotomy. Emergency remedian sternotomy was performed without aneurysmal injury and with exposure of the left femoral artery and femoral vein.

Aneurysmal resection and ascending aorta repair were performed without complication. Exposing peripheral vessels, and initiating cardiopulmonary bypass only after reentry, might be effective in resternotomy to approach ascending aorta pseudoaneurysms.

Thirty-one patients underwent combined TAR for aortic regurgitation AR with extended aortic aneurysm from the aortic root to the aortic arch. Aetiologies included acute type A aortic dissection in 12 cases, chronic aortic dissection in 8 cases and non-dissecting aneurysm in 11 cases.

There were 9 patients with Marfan syndrome. The preoperative severity of AR was mild in 4, moderate in 16 and severe in Even though half of those were emergent operations for acute aortic dissection, preoperative haemodynamic conditions were stable in all patients.

Other complications, such as neurological dysfunction or low cardiac output syndrome, were not observed. Follow-up was completed in No late death and thromboembolic complication occurred during follow-up. One patient required reoperation for AR. Freedom from moderate or severe AR at 3 and 5 years was The rate of freedom from reoperation during long-term follow-up was acceptable.

Further follow-up is required to evaluate this procedure. A year old man with ascending aortic aneurysm was referred because of a quadricuspid aortic valve. He underwent aortic root replacement with a valve-sparing technique. Under deep hypothermic circulatory arrest, replacement of the ascending aorta was successfully performed. The postoperative course was uneventful without recurrence of aortic regurgitation. We describe our experience with a patient who had metastasized pulmonary artery sarcoma, but survived 7 years after diagnosis.

A year-old man was diagnosed with pulmonary artery intimal sarcoma after resection of metastatic tumours to the bilateral lungs. The primary lesion in the pulmonary artery trunk extending into the bilateral branches was treated by tumour endoarterectomy followed by chemotherapy. He underwent resections of lung metastases two more times before detection of recurrent obstructive pulmonary artery sarcoma 4 years after the tumour endoarterectomy.

En bloc resection of the tumour including the pulmonary artery trunk, valve and interventricular septum was performed, and the right ventricular out flow tract was reconstructed with a stentless pulmonary valve and equine pericardium. He died of the disease soon after an operation for metastatic brain tumour 3 years later. Pulmonary artery sarcoma has a dismal prognosis, but aggressively repeated surgical interventions may lengthen survival.

Delayed awakening was defined as patients not waking up for more than 6 h after the termination of anaesthesia. Fourteen patients showed delayed awakening. Two patients 1. Our objective was to analyze the prognostic implication of COPD severity on outcomes after total aortic arch replacement. METHODS: Between October and December , patients undergoing total arch replacement through median sternotomy, who were elective cases with preoperative spirometry records, were retrospectively reviewed.

Symptoms of functional dyspnea and disability were also assessed. Multivariate logistic and Cox regression methods were used to determine if there was an independent association between COPD and short-term and long-term outcomes, respectively. A consistent trend of increasing frequency of postoperative respiratory complications with advanced airflow obstruction was noted. METHODS: From November to April , 70 patients underwent surgical management for aorta-related infection, including aortobronchial fistula in 12 patients, aorto-oesophageal fistula in 14 and aortoduodenal fistula in 4.

The location of infection was aortic root to arch in 22 patients, descending aorta in 29, thoraco-abdominal aorta in 12 and abdominal aorta in 7. Forty-seven patients had infections of the native aorta and 23 had postoperative graft infections.

Omental flap was installed in 29 patients and a pedicled latissimus dorsi muscle flap was used in 3. Since , we have been trying to resect not only the infected tissues, but also the surrounding aneurysmal wall as well. Late death occurred in 15 patients.

Overall survival at 3 years was Freedom from infection-related death of patients who had in situ graft replacement, endovascular repair or extra-anatomical bypass at 3 years was The mean age was Eight patients had non-dissecting thoracic aneurysm, 3 had chronic aortic dissection, 5 had oesophageal cancer and 1 had fish bone penetration.

Five patients were in shock. Four patients had previous thoracic endovascular aortic repair TEVAR in the descending aorta and 1 had hemi-arch replacement. The oesophagus was resected in 8 patients, and an omental flap was installed in 7 patients. For the 4 most recent cases, simultaneous resection of the aorta and oesophagus, in situ reconstruction of the descending aorta using rifampicin-soaked Dacron graft and omental flap installation were performed.

However, since , only 1 of 5 patients died pneumonia. All patients with oesophageal cancer died during follow-up.

Two patients underwent oesophageal reconstruction using a pedicled colon graft and one is on the waiting list for oesophageal reconstruction. One-stage surgery consisting of resection of the aneurysm and oesophagus, in situ reconstruction of the descending aorta and omental flap installation provided a better outcome in the AEF surgical strategy compared with conservative treatment.

METHODS: Between and , 9 patients with infected distal aortic arch aneurysms underwent total aortic arch replacement using antegrade selective cerebral perfusion. There were 4 male and 5 female patients with a mean age of All patients had penetrating atherosclerotic ulcer in the distal aortic arch, which formed saccular aneurysms. Four patients had preoperative hoarseness.

Causative microorganisms were identified by blood culture or aortic wall culture and were as follows: Candida albicans, Pseudomonas aeruginosa, Edwardsiella tarda, Streptococcus dysgalactiae, Listeria monocytogenes, Staphylococcus aureus 2 cases , and unknown 2 cases. Radical debridement with in situ total aortic arch replacement was performed in all patients, followed by the omental flap grafting in 7 patients. All surgery was performed on an urgent or emergency basis.

There was no in-hospital mortality, but 1 patient died of asphyxia 5 months after hospital discharge. Nafamostat mesilate NM is a synthetic protease-inhibiting agent that has not only potent inhibitory activity against coagulation factors Xlla, Xa but also an anti-inflammatory action. Herein is reported the authors' successful surgical experience using NM with low-dose heparinization in patients with AIE complicated by recent cerebral complications. Twenty-two of 28 patients had preoperative stroke, and six had active brain bleeding.

Surgery was performed at a mean of 2. The activated clotting time ACT was maintained at s by the precise administration of NM into a cardiotomy reservoir 0. Five patients There was no further aggravation of intracranial bleeding, and no new hemorrhagic stroke.

We investigated the hypothesis that the known antioxidant ascorbic acid, which can also promote elastin and collagen production by smooth muscle cells, would prevent AAA formation in a rat model.

Wrapping of the sheet was completed at the end of treatment for AAA creation. The aortic dilatation ratio was measured, and aortic tissues were further examined for oxidative stress and oxidative DNA damage using biochemical and histologic techniques. Objective: Abdominal aortic aneurysms AAAs are associated with oxidative stress and inflammatory response. Patients who underwent BPA showed improved mean pulmonary arterial pressure, pulmonary vascular resistance, and cardiac output Objectives: The present study analyzes the early patency of intercostal artery reconstruction, using graft interposition and aortic patch anastomosis, and determines the fate of reattached intercostal arteries after repair of thoracoabdominal aortic aneurysms.

Results: The hospital mortality rate was 7. Eleven patients 9. The average number of reconstructed intercostal arteries per patient was 3. The overall patency rate was Conclusions: Aortic patch anastomosis might offer better patency rates and prevent spinal cord ischemic injury compared with graft interposition.

Although aneurysmal changes in intercostal artery reconstructions are rare, large blocks of aortic wall reconstruction should be closely monitored. We herein present two cases of total arch replacement using a surgical technique designed to avoid the danger of DSWI. Total arch replacement via an antero-lateral thoracotomy with partial sternotomy can be one of the options for patients with a tracheostoma or after laryngectomy, and can both protect organs and avoid DSWI. Midsternotomy in patients with a coexisting tracheostomy is associated with a risk of deep sternal wound infection DSWI or mediastinitis.

Objective: Dipeptidyl peptidase-4 DPP-4 inhibitor, a novel antidiabetic drug, has a cardioprotective effect on ischemia-reperfusion injury through an antioxidant effect. However, the effect of DPP-4 inhibitor on aneurysm formation has not been investigated. We aimed to test the hypothesis that the DPP-4 inhibitor, alogliptin, attenuates vascular oxidative stress and thus inhibits abdominal aortic aneurysm AAA formation. Methods: AAAs were created with intraluminal elastase and extraluminal calcium chloride in 36 male rats.

Alogliptin was administered by gastric gavage once daily beginning 3 days before surgery. On day 7 after aneurysm preparation, reactive oxygen species ROS expression was semiquantified by dihydroethidium staining, and the oxidation product of DNA produced by ROS, 8-hydroxydeoxyguanosine 8-OHdG , was measured by immunohistochemical staining.

Blood glucose concentrations were measured. Hematoxylin and eosin and elastica Van Gieson stainings were performed on day 28, and the AAA dilatation ratio was calculated. Results: On day 7 six in each group , dihydroethidium staining of the aneurysm wall showed a reduced level of ROS expression 4.

On day 28 six in each group , the aortic wall in groups LD and HD was less dilated dilatation ratio: The difference in blood glucose levels among the three groups was not significant. Conclusions: The DPP-4 inhibitor, alogliptin, attenuates aneurysm formation and expansion dose-dependently in a rat AAA model via an antioxidative action. Secundum atrial septal defect ASD is the most common form of congenital heart disease in adults. Surgical and transcatheter closures of ASD are widely accepted therapeutic approaches.

In patients with severe pulmonary arterial hypertension PAH , however, the closure of the defect is still controversial. Subsequent shunt closure after targeted medical therapy can be an effective strategy in selected ASD patients with severe PAH. Objective: Little is known about the impact of preoperative renal function stratified by estimated glomerular filtration rate eGFR on outcomes of total aortic arch replacement TAR. The current study addressed this issue and identified a cutoff value of eGFR for the requirement of postoperative renal replacement therapy.

Methods: From January to May , consecutive patients who did not require preoperative hemodialysis were retrospectively studied after elective TAR. Results: The overall hospital mortality was 2.

A lower categories of eGFR were an independent risk factor for hospital mortality odds ratio, 0. A cutoff value for the requirement of postoperative renal replacement therapy was Midterm survival and freedom from major adverse cerebrocardiovascular events were worse across the levels of the lower categories of eGFR. Mean RV was Twenty-six patients Kaplan-Meier survival estimates at 1 and 5 years were We aimed to evaluate the severity of cirrhosis as a predictor of early and late outcomes after cardiovascular operations.

We retrospectively reviewed patients who underwent cardiovascular operations in our institute between October and April Liver cirrhosis was identified in 32 consecutive patients. TheMELD scorewas less than 10 category 1 in 10 patients, between 10 and No relationship was found between the Child-Pugh classification and long-term survival. Our results suggest that the MELD score is useful to predict hospital death and long-term survival after cardiac operations for patients with liver cirrhosis.

The MELD score was less than 10 category 1 in 10 patients, between 10 and Mean Japan score predicted 30 day mortality was 8. Permanent neurologic deficit occurred in 2. Survival at 5 and 10 years after surgery was During follow up period, there was only one total arch replacement related problem proximal anastomosis aneurysm. Freedom from additional aortic surgery and aortic related event at 5 and 10 years was The elephant trunk technique is used as a standard method in the approach to staged repair of extensive thoracic aneurysms.

Here, we present a rare case of a graft infection, in which vegetation was attached to the distal end of the elephant trunk. A year old male who had undergone total arch replacement with elephant trunk installation for type A aortic dissection was readmitted for high-grade fever.

At the time of admission, Osler's nodules were present and brain magnetic resonance imaging showed multiple small emboli and haemorrhages. Transoesophageal echocardiography could not locate any sign of infection within the cardiac chambers, but disclosed vegetation attached to the elephant trunk.

He underwent successful emergent graft replacement of the lesion, and no recurrence of the infection has been observed. METHODS: Echocardiographic data from 86 patients who underwent aortic root replacement with or without cusp repair were retrospectively reviewed. An analysis was conducted of the height difference between the level of the ventriculoaortic junction VAJ and the central free margin of the cusp, defined as the effective height EH , and the length from the aortic annulus to the edge of the body of Arantius, defined as the geometric height GH , in addition to root dimensions diameter of VAJ, sinus of Valsalva, and sinotubular junction.

We present a single center's experience of secondary interventions after thoracic endovascular aortic repair TEVAR. A total of 26 patients 19 male, mean age The median interval to secondary intervention was The in-hospital mortality rate was The cumulative survival rate of the 26 patients was Secondary surgical procedures after TEVAR can be performed with low mortality and morbidity, despite the precarious preoperative conditions and complex aortic pathologies of patients.

C by The Society of Thoracic Surgeons. OBJECTIVE: The effect of an atherothrombotic aorta on the short- and long-term outcomes of total aortic arch replacement, including postoperative neurologic deficits, remains unknown. We evaluated this relationship and also elucidated the synergistic effect of multiple other risk factors, in addition to an atherothrombotic aorta, on the neurologic outcome.

In-hospital deaths occurred in 2 patients, 1 2. Permanent neurologic deficits occurred in 4 2. Multivariate analysis demonstrated that the risk factors for transient neurologic deficits were an atherothrombotic aorta odds ratio, 4.

An exponential increase occurred in the probability of transient neurologic deficits with presence of an atherothrombotic aorta and other risk factors in relation to the cardiopulmonary bypass time. Survival at 3 years after surgery was significantly reduced in patients with vs without an atherothrombotic aorta Anticoagulation during cardiopulmonary bypass was maintained with low-dose heparin and additional nafamostat mesilate.

She had no further aggravation of the brain complication and recovered well with midterm mitral valve durability.

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