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Antitussive and mucoactive drugs. CYT1 es. This provides, and keeps the products inside your shopping cart. KRB1 ko. As she was tolerable to acetaminophen alone, we thought the culprit agent was maybe a levodropropizine tablet.

ABRILAR by Maria Victoria Mota on Prezi Next

Extracto de Hedera Helix 35 mg Niños de 2 a 5 años media cucharadita ( mL) cada 8 horas. Niños de 6 a 12 años 1 cucharadita (5mL) cada 8 horas. Prospantus® es un jarabe mucolítico y expectorante que se utiliza para el Jarabe para la tos en niños prospantus El extracto de la planta Hedera helix. Nuestros jarabes para la tos. Bisolvon Jarabe para niños mayores de dos años​. Ver. BisolHelix® de Origen Natural. Jarabe para la tos con Hedera helix. Ver. Prospan Cough Syrup is an effective treatment for chesty (productive) coughs. Prospan contains active ingredient Hedera Helix (Ivy Leaf Extract) which helps. Medicinal Ingredient: 7 mg/mL extract of dried ivy leaves (Hedera helix L.) · Infants under 1 year old, weighing kg ( lbs) or more: Consult a healthcare.

Hedera helix jarabe niños. The key to successful management is to establish a diagnosis and to treat the cause of cough.

Holzinger Felix, Chenot Jean-Francois; Systematic Review of Clinical Trials Assessing the Effectiveness of Ivy Leaf (Hedera Helix) for Acute Upper Respiratory. Troublesome and painful coughing is calmed but not blocked. Description. Ingredients. Hedera Helix Equivalent (Dry Leaf) mg/mL. Kid. BRONQUILAR EXTRACTO DE HEDERA HELIX (JARABE ml) Mucolítico, expectorante natural en base a extracto de hederá hélix. indicado. Download Citation | Tolerance, safety and efficacy of Hedera helix extract in inflammatory En todos ellos la población estudiada son niños de edades variables En ambos se ensaya el mismo preparado constituido por un jarabe con. Un estudio poscomercialización en niños confirmó estos resultados The effect of the whole extract of common ivy (Hedera helix) leaves and.

TOSTOP NATURE - SAVANT

The present invention relates to a novel formulation, comprising Hedera helix extract, Pelargonium sidoides extract and Zingiber officinale extract. ABRILAR es un extracto de Hedera hélix, cuyo principal principio activo es Alfa infantil de origen vegetal libre de leche a partir del nacimiento para niños con ALPV Inmunolive el jarabe que: * Equilibra y fortalece tu sistema inmunológico​.Hedera helix jarabe niños El jarabe Vaporex Helix con extracto Hedera Helix alivia la tos, y facilita la expulsión de la flema. Libérate de la congestión. #Vaporex. 2 Comments. Hedera Helix. Presentaciones: TOSTOP NATURE 7% x ml. Oral solution. TOSTOP NATURE it is indicated for the relief of dry cough and cough with difficult​. seditus niños.. seditus niños.. seditus jarabe tos infantil sante verte. € Tax excluded Delivery: 1 to 3 weeks. Quantity. Add to cart. Last items in. NIÑOS - ML. LATA. LATA HEDERA HELIX JARABE - ML. FRASCO X ML. FITOTUX. $ TERATOS MIEL NF NIÑOS. $. ,00 FARMA DE. suplementos-y-multivitaminas//SIMICOF-HEDERA-HELIX-BUGAMBILIA-​JARABE always seoauditing.ru#!

Hedera helix jarabe niños.

PRESENTACIONES ABRILAR JARABE (HEDERA HELIX) GR FCO X ML, SCANDINAVIA , , BISOLVON LINCTUS NINOS (BROMHEXINA) 4 MG FCO X ML. ABRIBRONC 35 MG/5ML SOLUCION HEDERA HELIX EXTRACTO (COMO FLUIDO AL DE RIZOMA JARABE DE JENGIBRE NIÑOS extracto fluido al.

La tos: ¿de verdad hay que calmarla? | Farmacia Principal img. Medicamentos para lo tos seca en niños y adultos. Cómpralos Hedera Helix - MEGALABS. Hedera helix L. extract Medication of natural origin used as an expectorant for productive. Senioral. Senioral jarabe adultos. Jar with Senioral jarabe niños.   Hedera helix jarabe niños TOSTOP NATURE is indicated for the relief of dry cough and cough with difficult expectoration in the bronchial catarrh. It contains Hedera Helix; a plant extract. Estos son los beneficios que te brinda Vaporex Helix Jarabe, el único que ayuda #VaporexHelix #QuédateEnCasa Dosis recomendada, para niños en edad Hedera Helix la encuentras en nuestro Vaporex Helix Jarabe que te ayudará a. Iso 6658 2017 تحميل جميع Eficacia de la miel para el tratamiento de la tos aguda en niños atendidos en forma Expectorant and Antitussive Effect of Hedera helix and Rhizoma coptidis​. Instrucciones De Manualidades Para Niños. Bordados Gratis Diseños gratis para Descargar ~ Bordados Descargar Gratis, mil Diseños Bordados.

Hedera helix jarabe niños

Cedric Balsamic is a cough syrup made of natural extract of Hedera Helix, with Honey and Thyme. For the entire family. Therapeutic Area Expectorant + Mucolitic. Excelente sabor; Uso Seguro en niños y adultos; Sin Alcohol; Sin Azúca; Sin Colorante; Jarabe con un solo componente. El Expectorante Natural Insuperable.  Hedera helix jarabe niños Ordinary Ivy or Climbing Ivy (Hedera helix) Leaves Alcohol-Free Original Tincture Naturalma Liquid Este jarabe viene muy bien como refuerzo natural en los procesos catarrales que cursan con flemas en el pecho, sobre todo para los niños. No está recomendados en niños de 3 meses el abrilar. El jarabe abrilar (extracto Hedera Helix) dentro de sus componentes contiene sorbitol.

Prospan by Helixia Cough Syrup – Kids - Pendopharm

  Hedera helix jarabe niños  

Hedera helix jarabe niños. EST3 - Novel formulations comprising herbaceous extracts - Google Patents

  Hedera helix jarabe niños  Lbd-pva6u3vrd ソフトウェア

Hedera helix jarabe niños

Dextromethorphan and chlorpeniramine are common ingredients of over-the-counter OTC cough pills. They are known to be safe when used alone, however, combination with other serotonergic drugs or use of an overdose can cause serotonergic toxicity.

We report on a year-old male and a year-old female who ingested an overdose of antitussive drugs containing dextromethorphan and chlorpeniramine. They commonly presented with altered mentality and hyperreflexia on both upper and lower extremities. After conservative therapies, they were discharged with alert mentality.

These cases are meaningful in that there are few cases of serotonin syndrome with an overdose of a combination of dextromethorphan and chlorpeniramine. Careful use with medication counseling for OTC cough pills is needed in order to prevent overdose of these ingredients.

Mucus viscosity, white blood cell and lymphocyte counts and tracheal wall morphometry were measured. Phenol red expectoration was estimated in mice after 7 d of daily administration of BP. BP and salbutamol 0. White blood cell, lymphocyte counts and tracheal morphometry were not significantly altered.

These properties may underscore its use in Nigerian ethnomedicine. To determine the concentration of menthol in rat plasma by GC. DAS 3. The results of the study showed that the pharmacokinetics behavior of menthol in ZCPDP was in conformity with two-compartment model characteristics. There were significant differences in pharmacokinetics of menthol in the range of Cough is the most frequent complaint from medical patients even though coughing is a protective reflex. The principle of relief from a cough is treatment of its underlying disease.

However, when the treatment of the cause of coughing is not effective, cough suppression therapy just to relieve the symptom may be attempted. Antitussives and mucoactive drugs are used for this purpose. Unfortunately, the currently available agents are not consistently effective and frequently have intolerable side effects. Therefore, understanding the side effects and mechanism of action of these agents is definitely needed. This review provides a summary of the currently available antitussives and mucoactives.

We experienced a case of immunoglobulin E IgE mediated anaphylaxis to levodropropizine. The patient was an year old Korean woman. After taking the common cold medication including acetaminophen, domperidone, and levodropropizine, skin rash, angioedema and anaphylaxis were developed immediately. As she was tolerable to acetaminophen alone, we thought the culprit agent was maybe a levodropropizine tablet. To confirm the culprit, she underwent skin prick test and oral drug provocation test with the suspected one.

The objective of this study was to compare the efficacy and safety of cough mixture containing pholcodeine and promethazine - Tixylix CS1 to a cough mixture which has noscapine, ammonium chloride, and sodium citrate CS2 as its constituents in treatment of children suffering from dry cough.

A total of patients were enrolled at 4 sites. Of these, 94 receiving CS1 and 99 receiving CS2 completed the study. Results of this study suggest that both the cough mixtures were comparable as per evaluation of their primary parameters. According to global assessment for efficacy and tolerability by parents on Day 7, Group CS1 performed better than CS2. To conclude, cough mixture combination of pholcodeine and promethazine - Tixylix exhibited efficacy and safety that was comparable with cough mixture which has noscapine, ammonium chloride, and sodium citrate.

It was proven to be efficacious, safe and well tolerated in the select population. Introduction: The cough is the more common respiratory symptom in children and adults. Objective: To present a revision on the neurophysiology and the methods for study of the consequence of the cough, as well as the pharmacotherapy and phonoaudiology therapy of the cough, based on the works published between and and indexed in the bases Medline, Lilacs and Library Cochrane under them to keywords "cough" or "anti-cough".

Synthesis of the data: The consequence of the cough involves activation of receiving multiples becomes vacant in the aerial ways and of neural projections of the nucleus of the solitary treatment for other structures of the central nervous system. Product Details. Reference Alma fit infusiones prevent Tonimer hipertonico spray Necessary 2 Preferences 4 Statistics 1 Cookie Policy Necessary Necessary cookies help make a website usable by enabling basic functions like page navigation and access to secure areas of the website.

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All parcels are still shipped on time but there are some delays due to Flight Cancellations. International delays apply. Please check your country on the link above. Each country has their own customs laws. Formulation 3 is less affected by light stress compared to other formulations and, therefore, the change in physical properties of formulation 3 is less than that of formulation 1 and formulation 2 at the end of the periods test.

Tabla 6: Fotoestabilidad de las formulaciones Table 6: Photoestability of formulations. In other words, the addition of Zingiber officinale to the formulation comprising the combination of Hedera helix and Pelargonium sidoides substantially increases the physical stability of the formulation Additionally, the fact that formulation 3 has a.

Improved physical stability is also an indication of having improved chemical stability. The present invention is further described by the following examples. The purpose of these examples is not to limit the scope of the present invention and their details should be evaluated in the light of the description given above.

La mezcla obtenida se somete al proceso de The solvents are mixed in the mixer until a homogeneous mixture is obtained.

Next, the inactive ingredients are added and mixed until a homogeneous mixture is obtained. Finally, Hedera helix extract, Pelargonium sidoides extract and Zingiber officinale extract, respectively, are added and mixed at high speed until a homogeneous mixture is obtained. The obtained mixture is subjected to the process of. At the end of the sedimentation period, the final product obtained is filled in suitable bottles. Ejemplo 2 Example 2.

Finally, it is added. The obtained mixture is subjected to the filtration process and allowed to settle. Ejemplo 3 Example 3. The solvents are mixed in the mixer until a homogeneous mixture is obtained. Finally, Hedera helix extract, Pelargonium sidoides extract, Zingiber officinale extract and Propolis extract, respectively, are added and mixed at high speed until a homogeneous mixture is obtained.

Ejemplo 4 Example 4. Finally, Hedera helix extract, Pelargonium sidoides extract, Zingiber officinale extract, and Propolis extract, respectively, are added and mixed at high speed until a homogeneous mixture is obtained.

Ejemplo 5 Example 5. Then it. Finally, Hedera helix extract, Pelargonium sidoides extract, Zingiber officinale extract and Glycyrrhiza glabra extract, respectively, are added and mixed at high speed until a homogeneous mixture is obtained. Ejemplo 6 Example 6. Ejemplo 7 Example 7. Finally, Hedera helix extract, Pelargonium sidoides extract, Zingiber officinale extract and Echinacea purpurea extract, respectively, are added and mixed at high speed until a homogeneous mixture is obtained.

Ejemplo 8 Example 8. Then, the inactive ingredients are added and mixed until a homogeneous mixture is obtained. Hedera helix extract, Pelargonium sidoides extract, Zingiber officinale extract and Echinacea purpurea extract, respectively, and mixed at high speed until a homogeneous mixture is obtained. Finally, Hedera helix extract, Pelargonium sidoides extract, Zingiber officinale extract, Propolis extract and Echinacea purpurea extract, respectively, are added and mixed at high speed until a mixture is obtained.

Ejemplo 10 Example Finally, Hedera helix extract, Pelargonium sidoides extract, Zingiber officinale extract, Propolis extract and Echinacea purpurea extract, respectively, are added and mixed at high speed until a homogeneous mixture is obtained.

Ejemplo 11 Example Finally, Hedera helix extract, Pelargonium sidoides extract, Zingiber officinale extract, Glycyrrhiza glabra extract and Echinacea purpurea extract, respectively, are added and mixed at high speed until a homogeneous mixture is obtained.

Ejemplo 12 Example Ejemplo 13 Example Finally, Hedera helix extract, Pelargonium sidoides extract, Zingiber officinale extract, Glycyrrhiza glabra extract and Propolis extract, respectively, are added and mixed at high speed until a homogeneous mixture is obtained.

Ejemplo 14 Example A formulation comprising Hedera helix extract, Pelargonium sidoides extract and Zingiber officinale extract. Formulation according to claims 1 to 2, wherein the weight ratio of Zingiber officinale extract to Hedera helix extract is between 1: 0. Formulation according to claims 1 to 3, wherein said formulation is administered orally, parenterally, ocularly, nasally, orally, sublingually and topically, preferably orally.

Formulation according to claim 4, wherein it is preferably in a liquid oral dosage form, more preferably in the form of syrup. Formulation according to any one of the preceding claims, further comprising at least one of the propolis extracts, Glycyrrhiza glabra and Echinacea purpurea. Formulation according to claim 6, wherein said formulation comprises Hedera helix extract, Pelargonium sidoides extract, Zingiber officinale extract and propolis extract. Formulation according to claim 7, wherein the weight ratio of Hedera helix extract, Pelargonium sidoides extract, Zingiber officinale extract and propolis extract is 6: 4: 1, respectively.

Formulation according to claim 6, wherein said formulation comprises Hedera helix extract, Pelargonium sidoides extract, Zingiber officinale extract and Glycyrrhiza glabra extract. Formulation according to claim 9, wherein the weight ratio of Hedera helix extract, Pelargonium sidoides extract, Zingiber officinale extract and Glycyrrhiza glabra extract is 7: 5: 5, respectively. Formulation according to claim 6, wherein said formulation comprises Hedera helix extract, Pelargonium sidoides extract, Zingiber officinale extract and Echinacea purpurea extract.

Formulation according to claim 11, wherein the weight ratio of Hedera helix extract, Pelargonium sidoides extract, Zingiber officinale extract and Echinacea purpurea extract is 7: 5: 8, respectively. Formulation according to claim 6, wherein said formulation comprises Hedera helix extract, Pelargonium sidoides extract, Zingiber officinale extract, propolis extract and Glycyrrhiza glabra extract.

Formulation according to claim 13, wherein the weight ratio of Hedera helix extract, Pelargonium sidoides extract, Zingiber officinale extract, propolis extract and Glycyrrhiza glabra extract is 6: 4: 1: 4, respectively.

Formulation according to claim 6, wherein said formulation comprises Hedera helix extract, Pelargonium sidoides extract, Zingiber officinale extract, propolis extract and Echinacea purpurea extract.

Formulation according to claim 15, wherein the weight ratio of Hedera helix extract, Pelargonium sidoides extract, Zingiber officinale extract, propolis extract and Echinacea purpurea extract is 6: 4: 1: 7, respectively.

Formulation according to claim 6, wherein said formulation comprises Hedera helix extract, Pelargonium sidoides extract, Zingiber officinale extract, Glycyrrhiza glabra extract and Echinacea purpurea extract.

Formulation according to claim 17, wherein the weight ratio of Hedera helix extract, Pelargonium sidoides extract, Zingiber officinale extract, Glycyrrhiza glabra extract and Echinacea purpurea extract is 7: 5: 5: 8 respectively. Formulation according to any one of the preceding claims, wherein said formulation comprises at least one pharmaceutically acceptable excipient selected from the group comprising fillers, solvents, pH adjusting agents, sweeteners, aromatic agents and preservatives.

USB2 es. EPB1 es. CYT1 es. DKT3 es. EAA1 es. EST3 es.

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It is also used against nausea, spasms and fever in children. Based on its antiseptic effect, stomach and intestine infections are used and even against food poisoning.

It also prevents blood clotting and has a fluidizing effect on the blood. It favors the cardiovascular system by making platelets less adherent, this in turn causes a decrease in circulatory system problems.

It is appetizing and can also be used against constipation. In addition to these, it has a warming and sedative effect on cough, flu, cold and other diseases of the respiratory system. In the prior art, many formulations are described, comprising herbaceous agents or combinations of herbaceous agents. Although there are a large number of formulations comprising the combination of herbaceous substances, the effects of a formulation comprising Hedera helix extract, Zingiber officinale extract and Pelargonium sidoides extract have so far been unknown.

Products used for medical purposes must incorporate the elements of quality, efficiency and reliability. A product can be a "medical" product only by having these elements.

For the product prepared from a herbaceous source to be used in medicine, it must be prepared from an effective and standardized extract, the pharmacological, clinical and toxicological results thereof must be established, as well as the product stability must be determined. Physical, chemical and microbiological factors play an important role in the stability of medicines or other products prepared for medical purposes. The question of stability does not depend only on a simple cause, but arises as a result of many factors.

Factors such as the interaction of active agents contained in a product, the interaction of excipients with each other or with active agents, pH, light, humidity and temperature are among the many elements that can influence the stability of such products.

Until recently, researchers have given considerable importance to the chemical stability of pharmaceutical products rather than their physical stability and have carried out many studies in this regard. However, in many cases they have shown how changes in the physical structure of the products are important for the quality of the product and for the durability of its technological, microbiological and biopharmaceutical properties. Consequently, it was demonstrated that, above all, the physical stability of a product has to be maintained to preserve its quality and other characteristics, and, therefore, to guarantee physical stability during the development of pharmaceutical products is as important or sometimes more important to ensure its chemical stability.

For this reason, when a novel formulation is developed, in addition to trying to achieve a formulation of good physical stability, the physical properties of this formulation must be made ideal to provide high compliance by the patient. However, it is very difficult to provide the conditions described above in formulations comprising herbaceous substances.

Due to some chemical, biological and physical properties characteristic of the herbaceous substances used in the formulation, there are some problems in obtaining a formulation comprising said substances, as well as having good physical stability and ideal physical properties in terms of compliance of the patient. The physical properties and physical stability of the formulation are directly affected by the characteristic features of the herbaceous substances included therein.

The herbaceous substance included in the formulation that has physical properties such as a bad taste, a bad smell, a bad color, which oxidizes easily and provides a suitable medium for the reproduction of microorganisms, adversely affects physical stability and physical properties of said formulation. In addition, in the case that a formulation comprises a combination of herbaceous agents, a correct selection of the herbaceous agents is of great importance, since more than one herbaceous agent present in the same formulation is capable of mutually affecting their respective properties.

In light of the foregoing, it would be desirable to provide a formulation, as well as a process for the preparation of this formulation, comprising combinations of herbaceous agents, capable of retaining physical stability for a long time, and having ideal physical properties in terms of patient compliance.

In detail, there is a need in the state of the art for a formulation comprising extracts of Hedera helix, Pelargonium sidoides and Zingiber officinale, and having ideal physical properties to ensure high compliance of the treatment by the patient and good physical stability, as well as a method to prepare this formulation, which is simple, cost effective and saves time. The main object of the present invention is to provide new formulations comprising Hedera helix extract, Pelargonium sidoides extract and Zingiber officinale extract, overcome the problems mentioned above and have advantages over said problems.

Another object of the present invention is to provide a formulation comprising Hedera helix extract, Pelargonium sidoides extract and Zingiber officinale extract with good physical stability.

Another object of the present invention is to provide a formulation comprising Hedera helix extract, Pelargonium sidoides extract and Zingiber officinale extract with a clear and homogeneous appearance.

Another object of the present invention is to provide a formulation comprising Hedera helix extract, Pelargonium sidoides extract and Zingiber officinale extract, which maintains physical stability and has improved physical properties as a result of the use of suitable excipients. Another object of the present invention is to provide a simple, economical and time-saving process for the preparation of formulations comprising Hedera helix extract, Pelargonium sidoides extract and Zingiber officinale extract.

Maintaining the physical stability of a pharmaceutical product can be guaranteed if there is no change in the physical structure of that product. Therefore, whether or not physical stability is maintained, it is evaluated by determining the changes in various physical properties of the product during the formulation development process. Properties such as color, smell, taste, pH, clarity, viscosity, homogeneity, density are among the physical properties of a pharmaceutical product are the basic physical properties that play a role in assessing its physical stability.

Surprisingly, in the studies of physical stability carried out during the development of a herbaceous formulation comprising Hedera helix extract and Pelargonium sidoides extract suitable for medical purposes, it is found that in the case of adding another herbaceous substance, Zingiber officinale, in the formulation, the physical stability of the product is improved and, therefore, physical properties such as color, smell, taste, pH, clarity, viscosity, uniformity and density were maintained for a longer time thereof at the time of preparing the formulation, such that physical stability was also maintained.

Density, clarity, homogeneity, viscosity and pH, taken into account when assessing its physical stability, are maintained for longer periods compared to those in the formulation comprising only extracts of Hedera helix and Pelargonium sidoides.

This, in turn, negatively influences the appearance, homogeneity and clarity of the formulation. In the light of the foregoing, the present invention provides a formulation, which is both homogeneous and clear, and has improved physical stability.

In accordance with the scope of the present invention, the percentage amount of Zingiber officinale extract represents an amount based on grams of Zingiber officinale extract per ml of formulation. Surprisingly, in the formulation according to the present invention, when Zingiber officinale extract and Hedera helix extract are used in specific weight proportions, that is, when the weight ratio of Zingiber officinale extract to Hedera helix extract is between 1: 0. Therefore, maintaining the quality, reliability and duration of the formulation for longer periods is provided with the formulation of the present invention that has improved physical stability.

Therefore, in the formulation according to the present invention, the weight ratio of Zingiber officinale extract to Hedera helix extract is between 1: 0. In the formulation according to the present invention administered orally in the form of syrup, the percentage amount of the Hedera helix extract based on the total volume of the formulation is between 0.

In this case, the percentage amount of the Hedera helix extract is the amount in grams of the Hedera helix extract contained in ml of formulation; The percentage amount of Pelargonium sidoides extract is the amount in grams of Pelargonium sidoides extract contained in ml of formulation.

In another aspect of the invention, the weight ratio of the Hedera helix extract with respect to the Pelargonium sidoides extract contained in the formulation according to the present invention is between 1: 0. In the formulations according to the present invention comprising Hedera helix extract, Pelargonium sidoides extract and Zingiber officinale extract in the amount and proportions mentioned above, the properties of taste, odor, appearance, viscosity, pH and clarity compared to the formulations They comprise only Hedera helix extract and Pelargonium sidoides extract does not change for longer periods and, therefore, physical stability is maintained for longer.

In another aspect, the formulation comprising Hedera helix extract, Pelargonium sidoides extract and Zingiber officinale extract can be administered orally, parenterally, ocularly, nasally, orally, sublingually and topically.

However, infants, children, the elderly, or patients who have difficulty swallowing cannot easily use solid oral dosage forms. Therefore, the formulation according to the present.

The invention is preferably in the form of a liquid oral dosage, more preferably in the form of syrup to ensure a high level of patient compliance and a satisfactory progression of the treatment. When the present invention comprises said herbal extracts with the aforementioned relationships, in comparison with the other relationships, the physical properties reach the optimum level in terms of patient compliance and the longer lasting physical stability is provided.

In another aspect of the present invention, said formulation, in addition to the above-mentioned herbal extracts, comprises at least one excipient.

Accordingly, the formulation according to the present invention comprises at least one pharmaceutically acceptable excipient selected from the group comprising fillers, solvents, pH adjusting agents, sweeteners, aromatic agents and preservatives. Therefore, when selecting the excipient for the formulation according to the present invention, care should be taken and the object of the present invention should be considered.

Suitable fillers contained in the formulation according to the present invention are selected from a group comprising, but not limited to, sucrose, sorbitol, xylitol, dextrose, fructose, maltitol, potassium sugar, aspartame, saccharin, sodium saccharin, anhydrous lactose or spray dried, mannitol, starch, cellulose preferably microcrystalline cellulose , and mixtures thereof; wherein the charge is preferably sorbitol.

Loads are used as dispersion medium in oral liquid formulations. In addition, they can be used to adjust the concentration of the formulation and improve the ease of manufacture. These excipients are preferably in the form of a solution in oral liquid formulations. Sorbitol has some physical and chemical properties that make it ideal for use as a suitable filler for the present invention. It is chemically inactive and is compatible with many other excipients.

In addition, it is easily soluble in water and helps maintain the stability of a formulation by increasing its viscosity. In addition to all these characteristics, sorbitol is also used as a sweetener in pharmaceutical formulations. Within the scope of the present invention, in the case that the weight ratio of the sodium citrate dihydrate to the citric acid monohydrate is 1: 2 and, therefore, the pH level is maintained at acidic levels, it is observed that it contributes to the improvement in the flavor of the formulation and also the maintenance of its physical stability due to the pH value that remains constant.

The percentage amount of citric acid monohydrate provided in said formulation based on the total volume of the formulation is between 0. The pH value of the formulation according to the present invention is between 2 and 6. Suitable preservatives contained in the formulation according to the present invention are selected from the group comprising, but not limited to, methylparaben and propylparaben and their salts e. Therefore, when a formulation according to the present invention contains the above indicated amounts of herbaceous extracts, its physical stability can be maintained for a longer time without containing a preservative and a more natural formulation can be obtained in comparison to the formulation that It comprises a preservative.

Suitable aromatic agents contained in the formulation according to the present invention are selected from the group comprising, but not limited to, fruit flavors such as orange, cherry, strawberry, banana, banana, cherry, lemon; aromas of cardamom, anise, mint, menthol, eucalyptus, vanillin and ethyl vanillin, and mixtures thereof; where the preferred aromatic agent is eucalyptus. As mentioned above, when eucalyptus is used as an aromatic agent, it is observed that it shows a support effect for said formulation due to the refreshing and softening effect of the smell and the patients to whom said formulation is administered feel instant relief and relief of the Symptoms, as well, helped them feel better in a shorter period of time.

It is also observed that patient compliance is improved, as well as patients' adherence to treatment is also accelerated due to the effect of the formulation according to the present invention comprising eucalyptus as the aromatic agent. In the present invention, effective results are obtained when the percentage amount of eucalyptus used as an aromatic agent based on the total volume of the formulation is between 0. Suitable sweeteners contained in the formulation according to the present invention are selected from the group comprising, but not limited to, sucralose, ammonium glycyrrhizinate, acesulfame-K, aspartame, saccharin or sodium and calcium salts of saccharin, sodium cyclamate, sucrose , fructose, glucose, sorbitol and mixtures thereof.

The percentage amount of the sweetener contained in the formulation according to the present invention based on the total volume of the formulation is between 0.

Suitable solvents contained in the formulation according to the present invention are selected from the group comprising, but not limited to, water soluble polar solvents such as propylene glycol, glycerin, water, ethanol, isopropyl alcohol and non-polar water insoluble solvents. The formulation according to the present invention preferably comprises propylene glycol, glycerin, water or ethanol, or a mixture thereof as a solvent.

When the percentage amount of ethanol contained in the formulation according to the present invention as a solvent based on the total volume of the formulation is between 0. Thus, in particular, by visual improvement of the physical properties of the formulation, a clearer and more homogeneous formulation can be obtained and patient compliance can be increased.

Said formulation, in addition to ethanol, also comprises water, propylene glycol and glycerin as solvent. The weight ratio of propylene glycol to glycerin contained in the formulation is between 1 and , preferably between 1 and , and more preferably between 2: 1 and 1: 5.

All herbaceous extracts included in the content of the formulation within the scope of the present invention can be obtained from the husk, leaf, flower, root or seed of respective plants.

The prior art methods are used to obtain all extracts according to the present invention. Within the scope of the present invention, the percentage amounts of substances by weight contained in the formulation represent the quantities of grams provided in the ml formulation. Please reach out to us to return your parcel. Once your return is received and inspected, we will send you an email to notify you that we have received your returned item.

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